Table 3.
Relative scavenging capacity of the serum as measured for multiple free radical species
| Free Radical |
||||||
|---|---|---|---|---|---|---|
| •OH | O2•− | RO• | ROO• | R• | 1ΔO2 | |
|
kserum/kCYPMPO |
kserum/kTEMP |
|||||
| CKD (n = 45) | 0.31 ± 0.05 | 0.38 ± 0.21 | 1.25 ± 0.31 | 0.16 ± 0.05 | 0.09 ± 0.05 | 6.94 ± 2.25 |
| percent vs control | 73 ± 12% | 158 ± 50% | 121 ± 30% | 123 ± 32% | 26 ± 14% | 57 ± 18% |
| healthy control (n = 30) | 0.42 ± 0.12 | 0.24 ± 0.07 | 1.03 ± 0.07 | 0.13 ± 0.04 | 0.35 ± 0.14 | 12.20 ± 2.07 |
| kserum/kGSH mM-GSHeq | kserum/kSOD U/ml-SODeq | kserum/kTROLOX mM-TROLOXeq | kserum/kLA mM-α-LAaeq | kserum/kCYPMPO mM-CYPMPObeq | kserum/kGSH µM-GSHeq | |
| CKD (n = 45) | 6.8 ± 1.1 | 16.0 ± 6.0 | 1.13 ± 0.28 | 1.52 ± 0.52 | 0.09 ± 0.05 | 24.8 ± 7.9 |
| healthy control (n = 30) | 9.4 ± 2.8 | 10.1 ± 1.9 | 0.93 ± 0.06 | 1.24 ± 0.47 | 0.35 ± 0.14 | 43.6 ± 7.3 |
Top panel: Scavenging capacities of the serum are calculated relative to that of CYPMPO (kserum/kCYPMPO in mM-CYPMPO eq unit). For singlet oxygen, its quencher 4-OH-TEMP was used as a detection reagent and the capacity is listed as kserum/kTEMP. Bottom panel: Scavenging capacities are converted into the equivalent units to pure scavengers. a α-lipoic acid. b There is no known scavengers for alkyl radical (R).