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. Author manuscript; available in PMC: 2012 Sep 4.
Published in final edited form as: J Mass Spectrom. 2010 Aug;45(8):841–860. doi: 10.1002/jms.1762

Figure 2.

Figure 2

Multiple stages of tandem MS for the characterization of mono-methylated adduct of the RNA oligonucleotide SL3: (a) products obtained by isolation/activation of monomethyl SL3 (MS2, precursor ion m/z 1617.02); (b) isolation/activation of the first-generation fragment produced by loss of methylguanine (MS3, m/z 1617.02 → m/z 1576.55 → products); (c) isolation/activation of the second-generation fragment induced by consecutive losses of methylguanine and guanine (MS4, m/z 1617.02 → m/z 1576.55 → m/z 1538.70 → products). All precursor ions selected at each stage had a 4– charge state. Reproduced with permission from reference 87.