Table 2.
Results of 12 and 72 h rapamycin treatment of Pten-cre neurons
| Pten-cre | 12 h rapamycin | 72 h rapamycin | |
|---|---|---|---|
| EPSC amplitude (in nA) | 3.83 ± 0.5; n = 39 | 3.91 ± 0.6; n = 46 | 2.49 ± 0.5**; n = 48 |
| RRP charge (in nC) | 1202 ± 170; n = 36 | 1166 ± 124; n = 42 | 442 ± 60***; n = 48 |
| RRP vesicles | 9397 ± 1662; n = 35 | 9723 ± 1043; n = 40 | 4888 ± 605**; n = 45 |
| mEPSC frequency (in Hz) | 5.50 ± 0.8; n = 36 | 7.97 ± 1.0*; n = 42 | 4.85 ± 0.8; n = 45 |
| mEPSC amplitude (in pA) | 41.2 ± 2.9; n = 36 | 36.1 ± 2.2; n = 42 | 25.7 ± 1.4***; n = 45 |
| Spontaneous release rate (in s−1) | 0.0007 ± 0.0001; n = 35 | 0.0012 ± 0.0002; n = 40 | 0.0011 ± 0.0002; n = 44 |
| Cm (pF) | 38.6 ± 4.6; n = 30 | 34.5 ± 3.4; n = 30 | 26.1 ± 1.8*; n = 34 |
| PPR (20 ms) | 1.29 ± 0.1; n = 30 | 1.26 ± 0.06; n = 26 | 1.11 ± 0.05; n = 28 |
| Pvr (in %) | 3.44 ± 0.5; n = 39 | 3.10 ± 0.2; n = 46 | 5.20 ± 0.8*; n = 48 |
Measurements are shown as mean ± SEM.
*p ≤ 0.05;
**p ≤ 0.01;
***p ≤ 0.001, compared to the other two groups with one-way ANOVA and Student–Newman–Keuls post-test.