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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Surgery. 2012 Sep;152(3):449–454. doi: 10.1016/j.surg.2012.06.011

Figure 4.

Figure 4

Human mesenchymal stem cells acquire cancer associated fibroblast markers after 12 hours culture in admixture with SK Hep1 cells. (A) rt-PCR for CAF marker SDF-1 expression shows untreated admixtures readily express SDF-1 mRNA which is suppressed in admixtures treated with OPN-R3-APT (p<0. 0001) and RGD (p<0. 0001). (B) rt-PCR for CAF marker tenascin C shows untreated admixtures also expressed tenascin C mRNA which is again suppressed in admixtures treated with OPN-R3-APT (p<0. 0001) and RGD (p<0. 0001). Negative controls with the addition of mutant-OPN-R3 or RGE were unchanged from null for both markers (p=NS)