FIGURE 6.
Effect of augmenting Biobrane with silver-nanoparticle PEMs on wound infection in mice inoculated with S aureus. Wounds were inoculated with 1.8 × 105 CFU/cm2 S aureus and covered with either untreated Biobrane (n = 10 mice) or Biobrane augmented with silver-nanoparticle PEMs (n = 10 mice). Augmentation of Biobrane with silver resulted in reductions in bacterial counts to levels significantly less than that of untreated Biobrane, and reaching levels below that considered significant for a clinical wound infection. Error bars denote standard error of the mean. Groups significantly different (Mann-Whitney U test, P < 0.001). Red line indicates initial inoculating dose.