Fig 7.

Postulated scheme by which inflammation contributes to retinal capillary degeneration in diabetes. The scheme shows a series of steps which were elucidated by inhibiting a specific protein (such as iNOS), and then determining which other steps (or proteins) also were inhibited (and thus were regulated by that protein). RAGE also fits into this scheme, but its position relative to many of these other abnormalities is not yet clear.