Figure 3. SdV-infection leads to Treg apoptosis in murine recipients.
A) Following epithelial regeneration, SdV or sham infection was induced (n=40 each group). Mice were then serially sacrificed and the frequency of Treg in the draining lymph nodes determined using flow-cytometry. B). At day 5 and day 7 (n=5 at each time point), Treg were stained with annexin V to determine apoptosis. C) At day 60, recipients were sacrificed and analyzed for intramural fibrosis of tracheal allografts.