Table 1.
Summary of Cord Blood Infusion Reactions with Cardiopulmonary Symptoms*
| Patient |
Cord Blood Characteristics |
Infusion Reaction |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Age | Sex | CB Unit |
ABO Compatible |
RBC Depleted |
CB Processing | Final Volume |
Onset | Symptoms | Ref |
| 1 | 16 | F | 1 | N | Y | Both diluted 1:3 HSA-Dextran 40 |
169 mL | < 5 min | Nausea, vomiting, hypertension, chest pressure, tachycardia, ↑QTc, ↑troponin, septal hypokinesis, ↓ left ventricular function. |
This Report |
| 2 | Y | Y | 201mL | 2 hours | Hives. | |||||
| 2 | 55 | M | 1+2 | Y | Y | None | 209 mL | 10 min | Chest pain, hypertension, nausea, hypoxia, pulmonary edema, ↑troponin, ARI. |
3 |
| 3 | 44 | F | 1 | Y | N | Both diluted HSA-Dextran 40 |
251 mL 52 mL |
50 min | Chest pain, ↑troponin, hypoxia, ↓EF (69→15%), pulmonary infiltrates, ARI. |
4 |
| 2 | Y | NA | ||||||||
| 4 | 65 | M | 1 | Y | NA | Both diluted HSA-Dextran 40 |
200 mL | First unit | Chest pain, ↑troponin, ↓EF (25%), ST changes, hypoxia, pulmonary edema, ARI. |
4 |
| 2 | Y | NA | 50 mL | |||||||
| 5 | 34 | F | 1 | N | N | Both diluted 1:4 HSA-Dextran 40 |
Total 500 mL |
50 mL | Chest pain, ↓EF (66→50%). | 4 |
| 2 | Y | N | During infusion |
Hypoxia, nausea, vomiting, chest pain, ↑troponin, ↓EF (50→40%), pulmonary infiltrates, global myocardial hypokinesis. |
||||||
| 6 | 20 | F | 1 | NA | N | None | 50 mL | During infusion |
Chest pain, hypertension, hypoxia, nausea, vomiting, hemoglobinuria. |
4 |
| 2 | NA | Y | Diluted HSA-Dextran 40 |
NA | ||||||
| 3 | NA | N | Diluted HSA-Dextran 40 |
114 mL | ||||||
| 7 | 60 | NA | 1 | NA | N | Centrifuged, resuspended HSA |
175 mL | 15 min | Nausea, vomiting, abdominal pain, hypertension, hypoxia, ST depression, ↑troponin, mild atrial hypokinesia. |
3 |
*
Abbreviations: CB, cord blood; EF, cardiac ejection fraction; HSA, human serum albumin; NA, not available; ARI, acute renal injury.