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(a) Cells grown on transwell inserts exhibit tight junction staining for occludin and ZO-1 (arrows) which was not observed in cells treated with Latrunculin A or Jasplakinolide. (b) Measurements of paracellular permeability indicate significant tight-junction disruption in Latrunculin treated cells. Statistically significant differences with no treatment control is indicated by * p < 0.05 and data are mean ± 95% confidence interval (n = 3 per group).
