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Direct phospholipid binding measurements
| FVIII mutants |
FV mutants |
||
|---|---|---|---|
| Mutant | KD, μM | Mutant | KD, μM |
| FVIIIWT | 0.46 ± 0.08 | FVWT | 0.7 ± 0.2 |
| FVIIIWW | 0.19 ± 0.03 | FVMF | — |
| FVIIILS | 0.33 ± 0.10 | FVLL | 1.4 ± 0.1 |
| FVIIIWW/LS | 0.19 ± 0.05 | FVMF/LL | 0.65 ± 0.06 |
— indicates that the signal was too small to fit, probably because of low FVMF concentration (see supplemental Figure 1B).
