Figure 2.

To cycle or to differentiate - the G1 phase of the cell cycle. Cells that have exited mitosis into G1 can either enter a state of quiescence (G0), differentiate along a particular lineage or progress to another cell division cycle. The process of decision making between these possibilities is governed by a multitude of different proteins. Proteins that are frequently overexpressed or mutated and hence contribute to leukemic transformation are marked in red. Tumor suppressor proteins are marked in green, proteins that contribute to differentiation are shown in orange. Therapeutic agents are marked in yellow. See text for details.