Table 3.
oPOSSUM analysis of over-represented transcription factor binding sites.
| Transcription Factor | Family | Target Genes | Z-Score |
|---|---|---|---|
| Class: Winged Helix-Turn-Helix | |||
| FOXI1 | Forkhead | 103 | 30.93 |
| FOXO3 | Forkhead | 112 | 29.9 |
| FOXD1 | Forkhead | 108 | 23.8 |
| Foxa2 | Forkhead | 102 | 22.82 |
| FOXA1 | Forkhead | 105 | 21.82 |
| Foxd3 | Forkhead | 97 | 21.76 |
| SPI1 | ETS | 130 | 17.32 |
|
| |||
| Class: Helix-Turn-Helix | |||
| Nkx2-5 | Homeo | 129 | 31.21 |
| HOXA5 | Homeo | 134 | 29.04 |
| Pdx1 | Homeo | 122 | 25.42 |
| Prrx2 | Homeo | 117 | 24.24 |
| Nobox | Homeo | 113 | 23.05 |
| ARID3A | Arid | 130 | 28.3 |
|
| |||
| Class: Other Alpha-Helix | |||
| SRY | HMG | 116 | 35 |
| SOX5 | HMG | 111 | 22.42 |
| Sox17 | HMG | 110 | 20.15 |
| SOX9 | HMG | 110 | 18.86 |
|
| |||
| Class: Zinc-Coordinating | |||
| Gata1 | GATA | 117 | 25.85 |
| Gfi | ββα-zinc finger | 118 | 18.11 |
|
| |||
| Class: Leucine Zipper | |||
| CEBPA | Zipper-type | 109 | 17.2 |