Table 2.
Pathogenic fungi and the antifungal agents in vitro activity**.
Microorganism | Antifungal agents | ||||
---|---|---|---|---|---|
Fluconazole | Voriconazole | Posaconazole | Echinocandin | Polyenes | |
Candida albicans | 1st line | 1st line | 1st line | 1st line | 1st line |
Candida glabrata | Unknown | 3rd line | 3rd line | 1st line | 2nd line |
Candida tropicalis | 1st line | 1st line | 1st line | 1st line | 1st line |
| |||||
Candida parapsilosis | 1st line | 1st line | 1st line | 2nd line | 1st line |
Candida krusei | No activity | 2nd line | 2nd line | 1st line | 2nd line |
Candida guilliermondii | 1st line | 1st line | 1st line | 2nd line | 2nd line |
| |||||
Candida lusitaniae | 3rd line | 2nd line | 2nd line | 2nd line | 2nd line |
Cryptococcus neoformans | 1st line | 1st line | 1st line | No activity | 1st line |
Aspergillus fumigatus | No activity | 1st line | 1st line | 2nd line | 2nd line |
Aserpgillus flavus | No activity | 1st line | 1st line | 2nd line | 2nd line |
| |||||
Aspergillus terreus | No activity | 1st line | 1st line | 2nd line | No activity |
Fusarium sp. | No activity | 2nd line | 2nd line | No activity | 2nd line |
Scedosporium apiospermum | No activity | 1st line | 1st line | Unknown | Unknown |
| |||||
Scedosporium prolificans | No activity | Unknown | Unknown | No activity | Unknown |
Trichosporon spp. | Unknown | 2nd line | 2nd line | No activity | 3rd line |
Zygomycetes (e.g., Absidia, Mucor, and Rhizopus) | No activity | No activity | 1st line | No activity | 1st line |
Dematiaceous molds
(e.g., Alternaria, Bipolaris, Curvularia, and Exophiala) |
Unknown | 1st line | 1st line | 3rd line | 3rd line |
| |||||
Dimorphic Fungi | |||||
Blastomyces dermatitidis | 3rd line | 2nd line | 2nd line | No activity | 1st line |
Coccidioides immitis | 1st line | 2nd line | 2nd line | No activity | 1st line |
Histoplasma capsulatum | 3rd line | 2nd line | 2nd line | No activity | 1st line |
Sporothrix schenckii | 3rd line | 2nd line | 2nd line | No activity | 1st line |
**Echinocandins, voriconazole, posaconazole, and polyenes have poor urine penetration.