(a)
| Drug A | Drug B | ||||||
|---|---|---|---|---|---|---|---|
| Interacting drug | Echinocandins | Azoles | Polyenes | ||||
| Anidulafungin | Caspofungin | Micafungin | Fluconazole | Voriconazole | Posaconazole | Amphotericin B and lipid formulations | |
| Amitriptyline | Inc A | ||||||
| Aminoglycosides | Inc nephrotoxicity | ||||||
| Antineoplastic drugs | Inc nephrotoxicity | ||||||
| Astemizole | |||||||
| Calcium channel blockers | Inc A | Inc A | |||||
| Carbamazepine | Dec B | Contraindicated Dec B | |||||
| Cidofovir | Inc nephrotoxicity | ||||||
| Cimetidine | Dec B | ||||||
| Cisapride | Contraindicated | Contraindicated | Contraindicated | ||||
| Cyclosporine | Slight Inc B |
Warning Inc B |
Inc A, Inc nephrotoxicity | Inc A, Inc nephrotoxicity | Inc A, Inc nephrotoxicity | Inc nephrotoxicity | |
| Dexamethasone | Dec B | ||||||
| Didanosine | |||||||
| Digitalis | Inc A | Drug interaction | |||||
| Efavirenz | Dec B | Dec B, Inc A | |||||
| Ergot Alkaloids | Contraindicated | Contraindicated | |||||
| Flucytosine | Drug interaction | ||||||
| Foscarnet | Inc nephrotoxicity | ||||||
| Glycosides | Drug interaction | ||||||
| H2 blockers, antacids, and scralfate | Dec B | ||||||
| Halofantrine | Contraindicated | ||||||
| Hydantoins, (phenytoin, Dilantin) | Dec B | Inc A, Dec B | Inc A, Dec B | Inc A, Dec B | |||
| Isoniazid | |||||||
| Fluconazole | Drug Interaction | ||||||
| Itraconazole | Drug Interaction | ||||||
| Ketoconazole | Drug Interaction | ||||||
| Long acting barbitunates | Contraindicated | ||||||
| Lovastatin/simvastatin | Inc A | ||||||
| Methadone | Inc A | ||||||
| Midazolam/triazolam, po | Inc A | Inc A | Inc A | ||||
| Nevirapine | Dec B | ||||||
| Nifedipine | Inc A | ||||||
| Oral anticoagulants | Inc A | Inc A | |||||
| Oral hypoglycemics (tolbutamide, glipizide, and glyburide) | Inc A | Inc A | |||||
| Pentamidine | Inc nephrotoxicity | ||||||
| Pimozide | Contraindicated Inc A | Contraindicated Inc A |
|||||
| Protease inhibitors | Inc A | ||||||
| Proton pump inhibitors | Dec B, Inc A | ||||||
| Quinidine | Contraindicated | Contraindicated | |||||
| Ritonavir (400 mg q 12 h) | Contraindicated | ||||||
| Rifampin/rifabutin | Dec B | Inc A, Dec B | Contraindicated Inc A, Dec B | Inc A, Dec B | |||
| Sirolimus | Inc A | Contraindicated, Inc B | |||||
| St. John's Wort | Contraindicated, Dec B | ||||||
| Tacrolimus | Dec A | Inc A, with toxicity | Inc A, with toxicity | Inc A, with toxicity | |||
| Terfenadine | Contraindication | Contraindicated | |||||
| Theophyllines | Inc A | ||||||
| Thiazide diuretics | Drug interaction | ||||||
| Trazodone | |||||||
| Warfarin | Inc A | ||||||
| Zidovudine | Inc A | Drug interaction | |||||