Table 5.
Pharmacokinetic parameters of the major echinocandins in clinical use*.
| Agent | C max | t 1/2 | V d | AUC | C t | FeU | FeS |
|---|---|---|---|---|---|---|---|
| Caspofungin | 7.64 | 10 | 0.4 | 88–115 | 0.15 | 1.40% | 35% |
| Micafungin | 4.95 | 14 | 0.23 | 111 | 0.19 | 0.70% | 40% |
| Anidulafungin | 2.07–3.5 | 25 | 0.5 | 44–53 | 0.26 | <1% | 30%, <10% unchanged |
*Dose 50 mg single dose, C max: maximum concentration, t 1/2: elimination half-life, V d: volume of distribution, AUC: area under the plasma concentration and time curve, C t: total clearance, FeU: fraction excreted in urine, FeS: fraction excreted in stool.