Table 2.
Baseline characteristics of chronic hepatitis C patients with genotype 1 and high viral loads treated with the NCT and the SOC.
| Patient no. | Age/gender | Body weight (kg) | BMI (kg/m2) | Liver histology (stage/grade) | HCV-RNA (TaqMan PCR Log lU/mL) | ALT (IU/mL) | Hb (g/dL) | Platelet (104/mL) | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| NCT | |||||||||
| 1 | 61/F | 48.5 | 20.9 | A1/F1 | 5.9 | 38 | 12.1 | 17.7 | SVR |
| 2 | 61/F | 46.1 | 20.4 | A1/F1 | 6.2 | 197 | 9.2 | 17.5 | SVR |
| 3 | 47/M | 67.0 | 21.1 | A1/F1 | 5.9 | 37 | 14.8 | 14.3 | SVR |
| 4 | 49/M | 60.0 | 19.8 | A2/F1 | 6.6 | 50 | 15.0 | 22.0 | SVR |
| 5 | 66/M | 78.0 | 24.5 | A2/F3 | 5.8 | 19 | 15.7 | 9.6 | SVR |
| 6 | 40/F | 73.0 | 27.1 | A2/F1 | 7.7 | 48 | 13.8 | 39.1 | TVR |
| 7 | 58/F | 55.0 | 20.6 | −/− | 6.4 | 32 | 12.6 | 17.7 | TVR |
| 8 | 73/M | 53.4 | 21.0 | A1/F1 | 6.4 | 20 | 12.1 | 22.4 | SVR |
| Mean ± SD | 58.9 ± 10.8 | 60.1 ± 11.6 | 21.9 ± 2.5 | 6.36 ± 0.61 | 55.1 ± 58.4 | 13.2 ± 2.1 | 18.9 ± 5.5 | ||
|
| |||||||||
| SOC | |||||||||
| 1 | 62/M | 61.0 | 19.7 | A2/F3 | 6.1 | 65 | 14.2 | 9.6 | NVR |
| 2 | 56/M | 61.3 | 19.6 | A2/F2 | 6.8 | 96 | 16.0 | 16.4 | TVR |
| 3 | 69/F | 48.2 | 21.4 | A2/F2 | 7.4 | 54 | 12.0 | 12.9 | NVR |
| 4 | 54/M | 77.9 | 24.0 | −/− | 6.8 | 79 | 15.8 | 7.9 | NVR |
| 5 | 64/M | 71.4 | 25.0 | A3/F2 | 7.3 | 273 | 14.2 | 13.9 | SVR |
| 6 | 69/F | 58.1 | 23.9 | A1/F1 | 5.7 | 31 | 15.7 | 13.4 | TVR |
| 7 | 56/M | 75.7 | 24.4 | −/− | 6.5 | 63 | 14.0 | 22.4 | SVR |
| 8 | 51/M | 49.5 | 16.5 | A1/F0 | 6.1 | 56 | 13.2 | 18.2 | SVR |
| Mean ± SD | 60.1 ± 6.9 | 62.9 ± 11.2 | 21.8 ± 3.0 | 6.59 ± 0.60 | 89.6 ± 76.5 | 14.4 ± 2.0 | 17.8 ± 6.1 | ||
NCT: novel combination treatment; cyclic and periodic IFN treatment (CPIT) consisting of induction treatment with natural interferon-β followed by maintenance treatment with natural interferon-α for 24 wks as induction approach followed by SOC for 48 wks, SOC: Standard of care; Standard of care; ribavirin plus pegylated interferon α 2b for 48 wks, SVR: sustained virologic response, NVR: No Virological Response, TVR: Transient Virological Response.