Table 1.

Various animal models used to study effect of RUNX1-ETO expression

Species	Descritpion	Hematopoietic phenotype	References
Drosophila melanogaster	Expression of RUNX1-ETO in eye	n/a	(179)
Drosophila melanogaster	Expression of RUNX1-ETO in blood cells	Increased number of blood progenitors	(146;180)
Danio rerio	Inducible expression of RUNX1-ETO by Hsp70 promoter	Increased number of immature blasts	(147;148)
Mus musculus	RUNX1-ETO knockin at Runx1 locus	Embryonic lethality due to hemorrhaging and block in hematopoiesis	(149;150)
Mus musculus	Inducible transgenic expression of RUNX1-ETO	Normal hematopoiesis	(12)
Mus musculus	Inducible Cre/loxP-mediated translocation of Runx1-Eto by Nestin Cre	Normal hematopoiesis	(139)
Mus musculus	Transgenic expression of RUNX1-ETO under MRP8 promoter	Normal hematopoiesis, treatment with ENU causes leukemia	(13)
Mus musculus	Inducible Cre/loxP RUNX1-ETO knockin expression by Mx1 Cre	Normal hematopoiesis, treatment with ENU causes leukemia	(140)
Mus musculus	Bone marrow transduction/transplantation with RUNX1-ETO	Abnormal myelopoiesis, no leukemia	(153)
Mus musculus	Bone marrow transduction/transplantation of ICSBP-deficient cells with RUNX1-ETO	Myeloid leukemia	(154)
Mus musculus	Bone marrow transduction/transplantation with RUNX1-ETO and TEL-PDGFbetaR	Myeloid leukemia	(155)
Mus musculus	RUNX1-ETO knockin at Sca1 locus	Myeloproliferative disease	(152)
Mus musculus	Bone marrow transduction/transplantation with RUNX1-ETO and FLT3 length mutation	Myeloid leukemia	(156)
Mus musculus	Bone marrow transduction/transplantation of human CD34+ cells with RUNX1-ETO in NOD/SCID mice	Abnormal myelopoiesis, no leukemia	(158)
Mus musculus	Bone marrow transduction/transplantation with WT1-overexpressing cells transduced with RUNX1-ETO	Myeloid leukemia	(181)
Mus musculus	Bone marrow transduction/transplantation with RUNX1-ETO9a	Myeloid leukemia	(142)
Mus musculus	Inducible Cre/loxP RUNX1-ETO knockin and HIP1-PDGFbetaR knockin expression by Mx1 Cre	Myeloid leukemia	(151)