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. 2012 Aug 13;7(8):e43022. doi: 10.1371/journal.pone.0043022

Figure 3. Pro-inflammatory cytokines inhibit P-gp function in GD65 BECs in a dose-dependent manner.

Figure 3

P-glycoprotein (P-gp) activity in brain endothelial cell (BEC) cultures derived from gestational day (GD) 65 male guinea pigs following treatment with 100–104 pg/mL A–C) interleukin-1β (IL-1β), D–F) interleukin-6 (IL-6) or G–I) tumor necrosis factor-α (TNF-α) for 1, 4 or 24 hours (N = 4). P-gp activity is displayed as percent change from untreated control cells (zero line). Values displayed as mean ± S.E.M. A significant difference from control indicated by (*) P<0.05; (**) P<0.01.