Table 6.
Multivariate analysis for reproductive hormones and DEHP metabolites concentrations in men (n=783)1
| Study | MEHP | MEHHP | MEOHP | ||||
|---|---|---|---|---|---|---|---|
| β | 95% CI | β | 95% CI | β | 95% CI | ||
| FSH | |||||||
| SFF | .01 | (−.03, .06) | .01 | (−.04, .06) | .01 | (−.04, .05) | |
| MGH | .02 | (−.02, .05) | −.02 | (−.07, .04) | −.02 | (−.07, .03) | |
| TOTAL | .01 | (−.01, .04) | −.01 | (−.04, .03) | −.01 | (−.05, .02) | |
| LH | |||||||
| SFF | .01 | (−.03, .05) | −.01 | (−.05, .03) | −.01 | (−.05, .03) | |
| MGH | −.01 | (−.04, .02) | −.002 | (−.05, .04) | .001 | (−.04, .05) | |
| TOTAL | −.01 | (−.03, .01) | −.02 | (−.05, .01) | −.02 | (−.05, .01) | |
| T | |||||||
| SFF | .01 | (−.03, .04) | −.01 | (−.04, .03) | −.01 | (−.04, .03) | |
| MGH | −.02 | (−.04, −.003)c | −.02 | (−.05, .01) | −.02 | (−.05, .02) | |
| TOTAL | −.01 | (−.03, .005) | −.01 | (−.03, .02) | −.01 | (−.03, .02) | |
| E2 | |||||||
| SFFa | −4.6 | (−10.4, 1.1) | −2.6 | (−8.4, 3.2) | −2.9 | (−8.8, 3.0) | |
| MGH | −3.1 | (−5.7, −.46)c | −1.9 | (−5.9, 2.1) | −1.5 | (−5.3, 2.4) | |
| TOTALb | −7.9 | (−12.4, −3.5)d | −3.4 | (−8.8, 1.9) | −3.0 | (−8.4, 2.3) | |
| SHBG | |||||||
| SFF | .05 | (.02, .09)d | .03 | (−.01, .07) | .03 | (−.01, .07) | |
| MGH | −.01 | (−.03, .02) | .02 | (−.02, .06) | .03 | (−.01, .07) | |
| TOTAL | .01 | (−.01, .03) | .03 | (.002, .06)c | .03 | (.005, .06)c | |
| FAI | |||||||
| SFF | −.05 | (−.08, −.02)d | −.04 | (−.07, −.004)d | −.04 | (−.07, −.01)d | |
| MGH | −.01 | (−.03, .01) | −.03 | (−.06, −.001)c | −.03 | (−.06, −.002)c | |
| TOTAL | −.02 | (−.04, .−.01)c | −.04 | (−.06, −.01)d | −.04 | (−.06, −.01)d | |
| FT | |||||||
| SFF | −.02 | (−.05, .01) | −.02 | (−.05, .01) | −.02 | (−.05, .01) | |
| MGH | −.02 | (−.04, −.004)c | −.03 | (−.06, .001) | −.03 | (−.06, .001) | |
| TOTAL | −.02 | (−.04, .−.004)c | −.02 | (−.04, −.001)c | −.02 | (−.04, −.001)c | |
| T/E2 | |||||||
| SFFa | .03 | (−.02, .07) | .004 | (−.04, .05) | .003 | (−.04, .05) | |
| MGH | .03 | (−.008, .06) | .02 | (−.04, .08) | .02 | (−.04, .08) | |
| TOTALb | .03 | (.001, .05)c | .01 | (−.02, .05) | .01 | (−.03, .05) | |
1
Controlling for age, age square, BMI, smoking status (current smoker vs. never smoked), ethnicity (African-American vs. others), study center (SFF vs. MGH), time of sample collection and time of sample collection squared. In addition, to take into account urinary dilution, SFF model also was adjusted by urinary creatinine values, MGH by specific gravity and the joint analysis (TOTAL) by ranking both variables.
a
N= 346 for E2
b
N= 766 for E2
c
P value≤.05,
d
P value≤.01
β= regression coefficient, CI= confidence interval
Log-transformations of phthalate metabolites and men sex hormones, except for E2 were used