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. Author manuscript; available in PMC: 2013 Jul 26.
Published in final edited form as: J Med Chem. 2012 Jul 17;55(14):6595–6607. doi: 10.1021/jm300714p

Figure 5.

Figure 5

Uptake of 2b with or without plasmin into human cancer cells. 250,000 cells per well of either MCF-7 (A) or MiaPaCa-2 (B) were treated with 0.5 µM 2b alone (dark diamonds) or 0.5 µM 2b with 0.2 U human plasmin (light diamonds) for various time periods and analyzed by flow cytometry for the presence of fluorescence due to the anthracycline fluorophore and compared to the fluorescence of untreated cells. Data representative of repeated measurements (at different timepoints) are shown here, with variation of approximately 10–20% between the experiments.