Table 2.
Growth inhibition of MCF-7 and MiaPaCa-2 cells by 24 h treatment of 2b with various activators and inhibitors. IC50 values are reported as log M and the value of U is defined as the hydrolysis of 1 µM 2b per min.
| Activation | Inhibition | ||||||
|---|---|---|---|---|---|---|---|
|
2b Alone |
2b + Plasmin (0.2 U) |
2b + Trypsin (0.2 U) |
2b + Papain (0.2 U) |
2b + Cathepsin B (0.2 U) |
2b + Aprotinin (5 µM) |
2b + Complete Protease Inhibition (1X) |
|
| MiaPaCa-2 | −6.6 ± 0.2 | −7.63 ± 0.03 | −7.58 ± 0.04 | −7.16 ± 0.03 | −6.80 ± 0.08 | −6.55 ± 0.06 | −6.4 ± 0.2 |
| MCF-7 | −6.7 ± 0.1 | −7.57 ± 0.02 | −7.5 ± 0.1 | −7.22 ± 0.05 | −6.92 ± 0.09 | −6.53 ± 0.04 | −6.6 ± 0.3 |