Starvation induces pumping in a muscarinic signaling-dependent manner
A) Starvation induced pumping in a muscarinic signaling-dependent manner. Pumping rates increased for first 2 hr in the absence of food. Two mutants defective in muscarinic signaling showed altered pumping rates compared to wild-type. gpb-2 mutants, which have upregulated muscarinic signaling, showed a higher pumping rate, and gar-3 mutants, which have downregulated muscarinic signaling, showed a lower pumping rate than wild-type.
B) A suggested pathway for function of the muscarinic receptor → MAPK pathway in starvation.