Table 1.
Functional annotation of 38 differentially expressed genes
| Notes | Generank | Fold Change | Edges | Gene Annotation |
|---|---|---|---|---|
|
Up-regulated genes |
|
|
|
|
| PLK1 |
12.04 |
5.44 |
49 |
regulates M phase of cell cycle |
| E2F1 |
10.51 |
3.01 |
18 |
mediate cell proliferation and p53-dependent/indepent apoptosis |
| AURKB |
10.07 |
5.13 |
39 |
mitosis checkpoint |
| CDK2 |
9.34 |
2.30 |
29 |
cell cycle checkpoint |
| PLCG2 |
8.93 |
2.18 |
10 |
crucial enzyme in transmembrane signaling |
| CD80 |
8.48 |
5.09 |
10 |
costimulatory signal for T cell activation |
| PIK3R3 |
7.39 |
2.94 |
15 |
responsible for a range of cell functions |
| CDC20 |
7.30 |
5.14 |
36 |
regulates multiple points of cell cycle |
| CDC6 |
6.90 |
5.75 |
26 |
initiates of DNA repliaction |
| AURKA |
6.88 |
5.27 |
21 |
mitosis checkpoint |
| CENPA |
6.87 |
6.87 |
28 |
mitosis checkpoint |
| BUB1B |
6.81 |
6.55 |
34 |
mitosis checkpoint |
| NUP37 |
6.37 |
3.08 |
29 |
mitosis checkpoint |
| MAD2L1 |
6.32 |
4.08 |
16 |
spindle-assembly checkpoint |
| BIRC5 |
6.04 |
5.53 |
36 |
negative regulator of apoptosis |
| CDC25A |
6.00 |
4.77 |
16 |
cell cycle checkpoint |
| CCNB1 |
5.81 |
5.81 |
18 |
cell cycle checkpoint |
| RPA3 |
5.64 |
2.42 |
17 |
required for DNA recombination, repair and replication |
| HJURP |
5.62 |
5.62 |
13 |
fuctions in chromosome segregation |
| KIF2C |
5.59 |
4.70 |
27 |
fuctions in chromosome segregation |
| CDK1 |
5.50 |
5.50 |
38 |
cell cycle checkpoint |
| CDCA8 |
5.45 |
5.27 |
26 |
mitosis checkpoint |
|
Down-regulated genes |
|
|
|
|
| FYN |
−19.27 |
−4.92 |
34 |
involved in B/T cell activation |
| CD3D |
−12.04 |
−10.50 |
19 |
involved in T/B-cell activation |
| CD4 |
−11.92 |
−4.97 |
20 |
MHC-II/T-cell receptor interacton |
| CD3G |
−11.91 |
−9.81 |
19 |
involved in T-cell activation |
| ZAP70 |
−11.69 |
−6.20 |
21 |
involved in T-cell development and activation |
| FOS |
−11.29 |
−8.32 |
14 |
involved in AP-1 and BCR/TCR signal pathway |
| HCK |
−10.11 |
−5.28 |
17 |
contributes to neutrophil migration and degranulation |
| CD247 |
−9.16 |
−9.16 |
19 |
regulates TCR expression and signal transduction |
| PRKCQ |
−9.10 |
−7.15 |
10 |
involved in T-cell activation |
| ITK |
−8.93 |
−9.22 |
15 |
involved in T-cell proliferation and differentiation |
| LCP2 |
−8.53 |
−4.27 |
14 |
involved in T-cell antigen receptor mediated signaling |
| CXCL1 |
−8.19 |
−8.19 |
13 |
has chemotactic activity for neutrophils |
| CD8A |
−8.08 |
−9.86 |
15 |
involved in T-cell mediated killing |
| ITGB5 |
−7.72 |
−5.16 |
11 |
receptor for fibronectin |
| VAV3 |
−7.60 |
−4.55 |
10 |
plays an important role in angiogenesis and FcϵRI signaling pathway |
| CXCR4 | −7.20 | −4.22 | 10 | cytokine-cytokine receptor interaction |
Note: Annotation and analysis results showed that the up-regulated genes were mainly related to cell cycle, mitosis, DNA replication, apoptosis regulation and etc., and the down-regulated genes were mainly related to T-cell (immunocytes) activation, MHC-II/TCR/BCR expression and interaction, cytokines interaction and etc.