. 2012 May 30;12:5. doi: 10.1186/1472-6823-12-5

Table 3.

Association of hypoglycemic events with glycemia medication class⁽¹⁾

	Intensive Glycemia			Standard Glycemia
Medication class	Person yrs of use of medication or combination	# of HMA events associated medication use	# events per 100 Person yrs	Person yrs of use of medication or combination	# of HMA events associated medication use	# events per 100 Person yrs
All Cases	17141.4	547	3.19	17709.9	185	1.04
Combination of medication classes
Oral medication only⁽²⁾	5691.6	110	1.93	9202.7	18	0.20
Metformin, TZD⁽³⁾	10342.1	300	2.90	5179.3	46	0.89
Metformin, Sulfonylurea, TZD⁽⁴⁾	6073.3	165	2.72	3360.7	18	0.54
Insulin only⁽⁵⁾	705.6	43	6.09	1476.6	39	2.64
Insulin plus metformin	8853.8	293	3.31	5116.1	82	1.60
Insulin plus insulin sensitizer⁽⁶⁾	10271.5	379	3.69	5991.6	111	1.85
Insulin plus secretagogue⁽⁷⁾	6747.5	226	3.35	3609.0	59	1.63

⁽¹⁾ participant reported a hypoglycemic event while taking the medication.

⁽²⁾ any combination of oral medications but no insulin.

⁽³⁾ metformin + TZD, regardless of other medications.

⁽⁴⁾ metformin + TZD + sulfonylurea, regardless of other medications.

⁽⁵⁾ any combination of insulin but no oral medications.

⁽⁶⁾ insulin sensitizer = TZD, metformin.

⁽⁷⁾ insulin secretogogues = sulfonylurea, meglitinides (prandin), incretins (exenatide).