Table 1.
Associations between MCM3 expression and clinicopathological factors
| |
MCM3 expression |
||
|---|---|---|---|
| Factor | Low | High | P |
| n(%) |
133 (59.4) |
91 (40.6) |
|
|
Age (continuous) |
|
|
0.858 |
| Mean |
67.36 |
67.25 |
|
| Median |
69.00 |
69.00 |
|
| Range |
46-81 |
47-83 |
|
|
Location |
|
|
0.893 |
| Dorsal trunk |
33 (26.0) |
23 (25.6) |
|
| Frontal trunk |
16 (12.6) |
12 (13.3) |
|
| Arms |
22 (17.3) |
18 (20.0) |
|
| Legs |
37 (29.1) |
23 (25.6) |
|
| Head and neck |
19 (15.0) |
14 (15.6) |
|
|
Unknown |
6 |
1 |
|
|
Histological subtype |
|
|
0.003 |
| SSM |
89 (66.9) |
53 (58.9) |
|
| LMM |
18 (13.5) |
5 (5.6) |
|
| NMM |
23 (17.3) |
30 (33.3) |
|
| Other |
3 (2.3) |
2 (2.2) |
|
|
Unknown |
|
1 |
|
|
Breslow thickness |
|
|
<0.001 |
| Mean |
1.48 |
1.94 |
|
| Median |
0.55 |
1.05 |
|
| Range |
0.08-40 |
0.15-14 |
|
|
Unknown |
1 |
1 |
|
|
Breslow categories |
|
|
<0.001 |
| ≤ 1 mm |
93 (70.5) |
44 (48.9) |
|
| 1.1-2.0 mm |
19 (14.4) |
15 (16.7) |
|
| 2.1-4.0 mm |
14 (10.6) |
23 (25.6) |
|
| > 4.0 mm |
6 (4.5) |
8 (8.9) |
|
|
Unknown |
1 |
1 |
|
|
Clark level |
|
|
<0.001 |
| II |
58 (43.9) |
19 (21.3) |
|
| III |
58 (43.9) |
39 (43.8) |
|
| IV-V |
16 (12.1) |
31 (34.8) |
|
|
Unknown |
1 |
2 |
|
|
Ulceration |
|
|
<0.001 |
| No |
122 (91.7) |
67 (74.4) |
|
| Yes |
11 (8.3) |
23 (25.6) |
|
|
Unknown |
|
1 |
|
|
Clinical stage |
|
|
0.003 |
| 1 |
108 (91.5) |
50 (75.8) |
|
| 2-4 |
10 (8.6) |
16 (24.2) |
|
|
Unknown |
15 |
24 |
|
|
Vascular invasion |
|
|
0.016 |
| No |
129 (97.0) |
81 (89.0) |
|
| Yes |
4 (3.0) |
10 (11.0) |
|
|
Mitotic count |
|
|
<0.001 |
| 0/mm2 |
87 (65.4) |
27 (29.7) |
|
| > = 1/mm2 |
46 (34.6) |
64 (70.3) |
|
|
Lymphocytic infiltrate |
|
|
0.463 |
| None-mild |
40 (30.5) |
23 (25.6) |
|
| Moderate-brisk |
93 (69.9) |
67 (74.4) |
|
|
Unknown |
|
1 |
|
|
Ki67 expression |
|
|
0.001 |
| Low |
100 (85.5) |
58 (65.9) |
|
| High |
17 (14.5) |
30 (34.1) |
|
|
Unknown |
16 |
3 |
|
|
RBM3 expression |
|
|
0.025 |
| Low |
46 (37.4) |
48 (52.7) |
|
| High |
77 (62.6) |
43 (47.3) |
|
| Unknown | 10 | 0 | |
P-values refer to Mann Whitney U test for comparison of medians and Chi square test for X × 2 tables. The categories marked as unknown were not included in the analysis.
Low RBM3 expression corresponds to a nuclear staining intensity of negative to moderate and high expression corresponds to strong staining as previously described [12].