Skip to main content
. 2012 Sep 4;7(9):e44371. doi: 10.1371/journal.pone.0044371

Figure 8. The hippocampal-dependent learning deficit in PRL null mice can be rescued by infusion of PRL into the hippocampus.

Figure 8

Following a 28-day infusion of either PRL or saline into the hippocampus, PRL−/− and PRL+/+ mice were tested on hippocampal-dependent learning using the Y-maze. When saline was infused into the hippocampus, the PRL null mice spent significantly less time in the novel arm compared to their wild-type littermates (***p<0.001; PRL−/− n = 5, PRL+/+ n = 5), indicating an impairment in hippocampal learning. Following infusion of PRL into the hippocampus, PRL null mice behaved similarly to their wild-type counterparts (no significant difference; PRL−/− n = 5, PRL+/+ n = 4), indicating that a lack of PRL in the null mice is responsible for the memory deficit.