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. 2012 Sep 4;7(9):e44498. doi: 10.1371/journal.pone.0044498

Figure 2. In vitro metabolite product identification of 4b and C1.

Figure 2

LC-MS identification of 4b (red) and C1 (green) metabolite products after incubation in mouse plasma and mouse hepatic microsomes. Metabolites of 4b included amide hydrolysis products M1 and M2, and the NADPH-dependent hydroxylated metabolites M4, M5 and M6. Metabolites of C1 included the amide hydrolysis product M3, the NADPH-dependent mono-hydroxylated products M7 and M8 and di-hydroxylated products M9 and M10. Boxed metabolites were present in both plasma and hepatic microsomal incubations, while the hydroxylated products were only present in hepatic microsomal incubations.