Figure 6. Comparison of the affinity with which each ErbB family member recruits proteins representing several molecular function categories.

Relative binding free energies of interactions described in Figure 5C were summed across all domains contained in a particular functional category [55] in (A) (see Table S16) and divided by the number of SH2 domains represented in each class in (B) to determine an average recruitment potential for SH2s from each functional class. (C) ErbB receptor enrichment and depletion for binding sites for functional groups depicted by Z-score transformation of the raw data as in Figure 5D.