Table 3. Correlations between KPNA2 expression and clinicopathological features of patients with OMGCT.
OMGCT | Immature teratoma | |||||
KPNA2 | KPNA2 | |||||
Characteristics | Low(n = 48) | High(n = 42) | P * value | Low(n = 30) | High(n = 8) | P * value |
Pathologic type | ||||||
Yolk sac tumor | 7 | 13 | ||||
Immature teratoma | 30 | 8 | ||||
Dysgerminoma | 2 | 9 | ||||
Embryonal carcinoma | 1 | 2 | ||||
Mixed germ cell tumor | 5 | 5 | ||||
Mature teratoma with malignant transformation | 3 | 5 | 0.002 | |||
Tumor size | ||||||
<19 cm | 27 | 25 | 16 | 4 | ||
≥19 cm | 21 | 17 | 0.832 | 14 | 4 | 1 |
Tumor grade | ||||||
G1 | 11 | 0 | ||||
G2 | 13 | 3 | ||||
G3 | 6 | 5 | 0.031 | |||
FIGO stage | ||||||
I | 25 | 19 | 13 | 0 | ||
II | 6 | 6 | 11 | 3 | ||
III–IV | 17 | 17 | 0.811 | 6 | 5 | 0.025 |
Recurrence and uncontrolled | ||||||
No | 38 | 24 | 25 | 3 | ||
Yes | 10 | 18 | 0.039 | 5 | 5 | 0.019 |
Ascitic fluid | ||||||
Without | 28 | 15 | 18 | 3 | ||
With | 20 | 27 | 0.037 | 12 | 5 | 0.426 |
Cytoreductive surgery | ||||||
Suboptimal | 0 | 6 | ||||
Optimal | 48 | 36 | 0.008 | 30 | 8 | 1 |
Ascitic fluid cytology | ||||||
Negative | 47 | 38 | 29 | 8 | ||
Positive | 1 | 4 | 0.181 | 1 | 0 | 1 |
CEA | ||||||
<5 µg/ml | 23 | 17 | 11 | 4 | ||
≥5 µg/ml | 5 | 3 | 2 | 0 | ||
Missing data | 20 | 12 | 0.703 | 17 | 4 | 1.0 |
Response to initial chemotherapy | ||||||
Sensitive | 35 | 24 | 22 | 3 | ||
Resistant or refractory | 6 | 14 | 3 | 5 | ||
Missing data | 7 | 4 | 0.037 | 5 | 0 | 0.01 |
AFP | ||||||
<25 µg/ml | 20 | 17 | 18 | 4 | ||
≥25 µg/ml | 20 | 18 | 9 | 4 | ||
Missing data | 8 | 7 | 1 | 3 | 0 | 0.433 |
HCG | ||||||
<3 µg/ml | 21 | 17 | 23 | 5 | ||
≥3 µg/ml | 2 | 11 | 2 | 1 | ||
Missing data | 25 | 14 | 0.022 | 5 | 2 | 0.488 |
SALL4 | ||||||
Low | 46 | 16 | 30 | 2 | ||
High | 2 | 11 | 0 | 0 | 6 | 0 |
Two-sided Fisher's exact test.
G1: Well differentiated (Low grade); G2: Moderately differentiated (Intermediate grade); G3: Poor differentiated (High grade).