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. 2012 Sep 4;7(9):e42992. doi: 10.1371/journal.pone.0042992

Table 3. Correlations between KPNA2 expression and clinicopathological features of patients with OMGCT.

OMGCT Immature teratoma
KPNA2 KPNA2
Characteristics Low(n = 48) High(n = 42) P * value Low(n = 30) High(n = 8) P * value
Pathologic type
Yolk sac tumor 7 13
Immature teratoma 30 8
Dysgerminoma 2 9
Embryonal carcinoma 1 2
Mixed germ cell tumor 5 5
Mature teratoma with malignant transformation 3 5 0.002
Tumor size
<19 cm 27 25 16 4
≥19 cm 21 17 0.832 14 4 1
Tumor grade
G1 11 0
G2 13 3
G3 6 5 0.031
FIGO stage
I 25 19 13 0
II 6 6 11 3
III–IV 17 17 0.811 6 5 0.025
Recurrence and uncontrolled
No 38 24 25 3
Yes 10 18 0.039 5 5 0.019
Ascitic fluid
Without 28 15 18 3
With 20 27 0.037 12 5 0.426
Cytoreductive surgery
Suboptimal 0 6
Optimal 48 36 0.008 30 8 1
Ascitic fluid cytology
Negative 47 38 29 8
Positive 1 4 0.181 1 0 1
CEA
<5 µg/ml 23 17 11 4
≥5 µg/ml 5 3 2 0
Missing data 20 12 0.703 17 4 1.0
Response to initial chemotherapy
Sensitive 35 24 22 3
Resistant or refractory 6 14 3 5
Missing data 7 4 0.037 5 0 0.01
AFP
<25 µg/ml 20 17 18 4
≥25 µg/ml 20 18 9 4
Missing data 8 7 1 3 0 0.433
HCG
<3 µg/ml 21 17 23 5
≥3 µg/ml 2 11 2 1
Missing data 25 14 0.022 5 2 0.488
SALL4
Low 46 16 30 2
High 2 11 0 0 6 0
*

Two-sided Fisher's exact test.

G1: Well differentiated (Low grade); G2: Moderately differentiated (Intermediate grade); G3: Poor differentiated (High grade).