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. 2012 Sep 4;7(9):e41879. doi: 10.1371/journal.pone.0041879

Figure 1. Poly I:C increases susceptibility to bacterial infection of the lung.

Figure 1

A. Animals were administered i.n. poly I:C (50 µg), TLR7 agonist (imiquimod 50 µg or gardiquimod 50 µg) , or saline vehicle daily for 2 days. Twenty-four hours after the last dose, animals were given i.t. S. pneumoniae (900 CFU in 30 µl). On day 3, lungs were harvested for enumeration of CFU. *, p<0.05 compared to saline and TLR7 agonist by one-way ANOVA. Data combined from 2 separate experiments. B. Animals were administered i.n. poly I:C (50 µg) or saline vehicle daily for 3 days, followed by i.t. S. aureus (MRSA, LAC USA300; 6×106 CFU) 24 hours later. Lungs were harvested 24 hours after bacterial infection for enumeration of CFU. *, p<0.05 compared to saline group. Data is representative of 2 independent experiments.