Figure 5. Effect of costimulation and IL-12p70 blockade on Th1 polarization by TLR-3-DCs.
TLR-3-DCs generated from peripheral blood of 6 healthy donors were cocultured with CD3-selected autologous T cells for 4 days either alone or with addition of various combinations of blocking antibodies. Supernatants were analyzed for secretion of IFN-γ by ELISA. T cells without DC stimulation were used as a negative control. Box-and-whisker plots for the different conditions are shown. *, p<0.05.
