Table 3. Burden of disease ranking of the top 20 infectious diseases or pathogens using Ontario Burden of Infectious Disease Study (ONBOIDS) and Global Burden of Disease (GBD) study methodologies, Ontario, Canada.

Rank	ONBOIDS methodology				GBD methodology				Change in Ranka
	Infectious Disease/Pathogen	YLL	YERF	HALYs	Infectious Disease/Pathogen	YLL	YLD	DALYs
1	Hepatitis C virus	8823	983	9807	Human immunodeficiency virus	2712	6731	9443	+5
2	Streptococcus pneumonia	6669	1601	8270	Hepatitis C virus	4203	2042	6245	−1
3	Escherichia coli	7485	341	7826	Streptococcus pneumoniae	2617	3309	5926	−1
4	Human papillomavirus	6191	1418	7609	Human papillomavirus	2861	1704	4565	0
5	Hepatitis B virus	6918	86	7004	Escherichia coli	2833	550	3383	−2
6	Human immunodeficiency virus	5036	1312	6349	Hepatitis B virus	3177	143	3320	−1
7	Staphylococcus aureus	3740	400	4140	Influenza virus	948	1678	2626	+1
8	Influenza virus	2482	1076	3558	Staphylococcus aureus	1529	789	2318	−1
9	Clostridium difficile	3216	107	3323	Rhinoviruses	51	2047	2098	+1
10	Rhinoviruses	125	1615	1740	Clostridium difficile	1162	169	1331	−1
11	Respiratory syncytial virus	968	397	1364	Respiratory syncytial virus	363	547	910	0
12	Parainfluenza virus	601	259	861	Chlamydia	8	883	891	+6
13	Group A streptococcus	598	216	814	Adenovirus	117	676	793	+7
14	Haemophilus influenzae	649	125	774	Group A streptococcus	242	410	652	−1
15	Group B streptococcus	603	123	725	Parainfluenza virus	233	376	609	−3
16	Tuberculosis	675	16	691	Group B streptococcus	251	270	521	−1
17	Legionellosis	588	40	628	Haemophilus influenzae	254	241	495	−3
18	Chlamydia	19	442	461	Varicella	63	291	354	+1
19	Varicella	150	303	453	Tuberculosis	291	42	333	−3
20	Adenovirus	301	150	451	Legionellosis	228	94	322	−3
	Total	55837	11010	66848	Total	24143	22992	47135

a – denotes the change in rank of an infectious disease/pathogen from its rank using the ONBOIDS methodology to its rank using the GBD methodology.

YLL = years of life lost to premature mortality; YERF = year-equivalents of reduced functioning; HALY = health-adjusted life years; YLD = years of life lived with disability; DALY = disability-adjusted life years.