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(A) Sequence of states leading to fusion pore formation and (B) the corresponding states of the syb2 TM domain from the simulations shown in Fig. 5. Zippering of the SNARE complex leads to helical extension, which in turn leads to force transfer and TM domain tilt as indicated in states i–iv. Fusion pore formation (vi) could proceed via the stalk state (v) or could be induced via the transition from state iii to iv.
