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Model of a dynamic UTP-enriched TC. The schematic shows that labeled UTPs mark both transcription sites and nascent transcripts. (Insets) Labeling of TCs depends on transcription, where the TCs colocalize with transcriptionally active RNA pol II; with transcription inhibition, colocalization with RNA pol is reduced and the TCs become more mobile. The mobility of these TCs further depends on the nuclear mesh of chromatin and laminB1.
