Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Thr56/Ile is responsible for the rat vs. human difference in potency of block by α-CTx RgIA. (A) Mutation of Thr56 in the rat α9 subunit to Ile, found in homologous position in the human subunit, shifts the potency of α-CTx RgIA towards that of the human receptor. (B) Replacement of Ile56 in human α9 to Thr56, found in rat α9, shifts the potency of RgIA towards that of the rat receptor. Values are mean ± SEM from at least three oocytes and are shown in Table 2.
