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. Author manuscript; available in PMC: 2012 Sep 5.
Published in final edited form as: Prog Brain Res. 2012;196:193–213. doi: 10.1016/B978-0-444-59426-6.00010-0

Table 2.

Transgenic mouse lines expressing genetically encoded calcium indicators

Name Method of
generation		 Promoter
used		 Cell type examined ΔF/F (or ΔR/R) Reference
Ptetbi-Cg2/luc (lines MTH-Cg2-14 and MTH-Cg2-19) Conventional transgenic, crossed to αCaMKII-tTA tetO Hippocampal or cortical pyramidal neurons ~4% (wide-field) or ~10% (2-photon) in response to short trains of action potentials,
2–8% (wide-field) or 20–100% (2-photon) in response to synaptic stimulation		 (Hasan et al., 2004)
Ptetbi-IP/luc (line MTH-IP-12) Conventional transgenic, crossed to αCaMKII-tTA tetO Hippocampal or cortical pyramidal neurons −2% (wide-field) or −30% (2-photon) in response to synaptic stimulation (Hasan et al., 2004)
Retina whole mount −10% (2-photon) in response to light
Olfactory bulb in vivo −8% (wide-field) in response to odor
pCAGGS-YC3.60pm Conventional transgenic CAGGS Hippocampal CA1 region 2–3% (wide-field) in response to synaptic stimulation (Nagai et al., 2004)
Kv3.1-G-CaMP2 (line 846) Conventional transgenic Kv3.1 Cerebellar granule cells 5–25% (wide-field at 60×) or ~50% (2-photon) in response to 10 stimuli at 100 Hz (Diez-Garcia et al., 2007; Diez-Garcia et al., 2005)
tetO-G-CaMP2 Conventional transgenic, crossed to OMP-ires-tTA tetO VNO olfactory sensory neurons 20% to >100% (2-photon) in response to pheromone stimuli (He et al., 2008)
Thy1-CerTN-L15 (line C) Conventional transgenic Thy1.2 Cortical layer 2/3 pyramidal neurons ~4% (2-photon) per action potential, 30–60% (2-photon) in response to iontophoretic glutamate stimulations (Heim et al., 2007)
Ai38 (GCaMP3) Knock-in to the Rosa26 locus CAG promoter (with floxed-stop cassette and WPRE) Cortical layer 2/3 neurons (Zariwala et al., in revision)