Table 3.
RR of type 2 diabetes (95% CI) according to serum ferritin, sTfR and the ratio of sTfR to ferritin
| Risk factor | RR (95% CI) | p trend | ||||
|---|---|---|---|---|---|---|
| Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 | ||
| Ferritin | ||||||
| Men, mg/l | <8.00 | 8.00 to <13.0 | 13.0 to <19.0 | 19.0 to <28.0 | ≥28.0 | |
| Women, mg/l | <2.00 | 2.00 to <3.89 | 3.89 to <6.39 | 6.39 to <11.0 | ≥11.0 | |
| Model 1 | 1 | 0.95 (0.59, 1.50) | 1.49 (1.00, 2.24) | 1.54 (1.03, 2.31) | 2.00 (1.35, 2.95) | <0.001 |
| Model 1 + hs-CRP | 1 | 1.01 (0.63, 1.63) | 1.56 (1.03, 2.37) | 1.65 (1.09, 2.50) | 2.09 (1.40, 3.12) | <0.001 |
| Model 1 + GGT and ALT | 1 | 0.91 (0.57, 1.46) | 1.45 (0.97, 2.17) | 1.51 (1.01, 2.26) | 1.74 (1.17, 2.60) | <0.001 |
| Model 1 + fetuin-A | 1 | 0.94 (0.59, 1.51) | 1.53 (1.01, 2.30) | 1.58 (1.05, 2.38) | 2.13 (1.43, 3.16) | <0.001 |
| Model 1 + adiponectin | 1 | 0.92 (0.57, 1.49) | 1.52 (1.00, 2.30) | 1.55 (1.03, 2.33) | 1.95 (1.31, 2.90) | <0.001 |
| Model 1 + HDL-cholesterol, triacylglycerol | 1 | 1.00 (0.62, 1.61) | 1.49 (0.99, 2.25) | 1.49 (0.99, 2.23) | 1.80 (1.22, 2.66) | <0.001 |
| Model 2 | 1 | 1.00 (0.61, 1.65) | 1.49 (0.97, 2.30) | 1.59 (1.05, 2.42) | 1.73 (1.15, 2.61) | 0.002 |
| sTfR | ||||||
| Men, mg/l | <0.90 | 0.90 to <1.00 | 1.00 to <1.10 | 1.10 to <1.30 | ≥1.30 | |
| Women, mg/l | <0.80 | 0.80 to <0.89 | 0.89 to <1.00 | 1.00 to <1.20 | ≥1.20 | |
| Model 1 | 1 | 1.37 (0.89, 2.12) | 1.83 (1.20, 2.79) | 1.52 (1.03, 2.24) | 1.22 (0.81, 1.86) | 0.64 |
| Model 1 + hs-CRP | 1 | 1.42 (0.92, 2.19) | 1.87 (1.23, 2.85) | 1.51 (1.02, 2.23) | 1.18 (0.78, 1.80) | 0.85 |
| Model 1 + GGT and ALT | 1 | 1.33 (0.86, 2.07) | 1.81 (1.19, 2.76) | 1.46 (0.99, 2.16) | 1.19 (0.78, 1.81) | 0.75 |
| Model 1 + fetuin-A | 1 | 1.36 (0.88, 2.10) | 1.78 (1.17, 2.71) | 1.48 (1.00, 2.18) | 1.14 (0.75, 1.73) | 0.94 |
| Model 1 + adiponectin | 1 | 1.40 (0.89, 2.20) | 1.81 (1.17, 2.81) | 1.63 (1.09, 2.45) | 1.30 (0.84, 2.00) | 0.38 |
| Model 1 + HDL-cholesterol, triacylglycerol | 1 | 1.47 (0.94, 2.30) | 1.93 (1.25, 2.97) | 1.50 (1.00, 2.23) | 1.36 (0.89, 2.08) | 0.47 |
| Model 2 | 1 | 1.38 (0.86, 2.20) | 1.87 (1.20, 2.93) | 1.47 (0.97, 2.22) | 1.21 (0.78, 1.89) | 0.80 |
| sTfR-to-ferritin ratio | ||||||
| Men, (mg/l)/(mg/l) | <0.04 | 0.04 to <0.05 | 0.05 to <0.08 | 0.08 to <0.13 | ≥0.13 | |
| Women, (mg/l)/(mg/l) | <0.09 | 0.09 to <0.15 | 0.15 to <0.25 | 0.25 to <0.50 | ≥0.50 | |
| Model 1 | 1 | 0.66 (0.48, 0.90) | 0.59 (0.43, 0.82) | 0.63 (0.45, 0.88) | 0.50 (0.34, 0.73) | <0.001 |
| Model 1 + hs-CRP | 1 | 0.67 (0.49, 0.91) | 0.59 (0.42, 0.82) | 0.63 (0.45, 0.89) | 0.47 (0.32, 0.70) | <0.001 |
| Model 1 + GGT and ALT | 1 | 0.72 (0.52, 0.99) | 0.66 (0.47, 0.91) | 0.69 (0.49, 0.98) | 0.56 (0.38, 0.83) | 0.004 |
| Model 1 + fetuin-A | 1 | 0.64 (0.46, 0.87) | 0.57 (0.41, 0.79) | 0.58 (0.41, 0.82) | 0.46 (0.32, 0.68) | <0.001 |
| Model 1 + adiponectin | 1 | 0.71 (0.51, 0.97) | 0.62 (0.44, 0.87) | 0.64 (0.45, 0.92) | 0.52 (0.35, 0.76) | <0.001 |
| Model 1 + HDL-cholesterol, triacylglycerol | 1 | 0.69 (0.50, 0.95) | 0.64 (0.46, 0.89) | 0.71 (0.50, 1.00) | 0.55 (0.37, 0.80) | 0.002 |
| Model 2 | 1 | 0.76 (0.54, 1.06) | 0.67 (0.47, 0.96) | 0.70 (0.48, 1.02) | 0.57 (0.38, 0.85) | 0.005 |
Model 1 is adjusted for age, sex, BMI, waist circumference, sports activity, bicycling, education, occupational activity, smoking habit and alcohol consumption
Model 2 is adjusted for factors in model 1 and GGT, ALT, fetuin-A, hs-CRP, adiponectin, HDL-cholesterol and triacylglycerol concentrations