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. 2012 Sep 5;3:312. doi: 10.3389/fmicb.2012.00312

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Copyright © 2012 Yokoyama, Oka, Kojima, Nagano, Okabe, Katayama, Wakita, Kanda and Sato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Flow chart for screening chemical compounds against SaV protease. Pharmacophore-based in silico screening (Schuster et al., 2006a,b; Kirchmair et al., 2007) was applied to extract the lead compounds having structural features that resembled those of the substrates of SaV protease. One hundred and fifty-one compounds exhibiting some similarities to the authentic substrates were further assessed with respect to their inhibitory activity against SaV protease. With this strategy, we could obtain three compounds that inhibited the processing of the SaV ORF1 polyprotein.