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. Author manuscript; available in PMC: 2012 Sep 5.
Published in final edited form as: J Med Chem. 1987 Jan;30(1):211–214. doi: 10.1021/jm00384a037

Figure 1.

Figure 1

Synthesis of xanthine derivatives. Reagents: (a) EtOH/HCl,7 50 °C (3) or R’OH/DMAP/EDAC (4); (b) 70% ethylamine, aqueous (5) or ethylenediamine, neat6 (6, 9); (c) DCC/HOBt; (d) HBr/HOAc. R = Me, Et, or n-Pr, corresponding to compound suffixes a, b, and c, respectively.