Figure 7.
rs17525495 genotype influences TB meningitis survival, inflammation, and treatment response. (A) Mortality from TB meningitis for all patients (treated and untreated with dexamethasone (DEX)), stratified by rs17525495 genotype (P=0.02, log rank test). (B) Median pre-treatment leukocyte counts in cerebrospinal fluid stratified by rs17525495 genotype (P=0.006, one-way ANOVA). (C) Influence of adjunctive dexamethasone treatment on patient survival for all genotypes. Treatment effect is not significant (P=0.2). (D) Survival among patients not treated with dexamethasone, stratified by rs17525495 genotype (P=0.042, log rank test) (E) Survival among patients treated with dexamethasone, stratified by rs17525495 genotype (P=0.005, log rank test). See also Figure S7 and Tables S1 and S2.