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Lack of Hsp72 strongly inhibits tumor development. (A) Hsp72 depletion suppresses tumor emergence in xenografts. Growth curves of individual tumors in xenografts of Her2-expressing control (Cont.) and shHsp72 MCF10A cells. (B) Levels of Hsp72 were restored in xenograft tumors derived from shHsp72 cells. (C) Effect of Hsp72 on mammary tumor incidence in Her2-expressing mice.
