Table 2.
Selected randomized controlled trials of treatments for BED
| Study | Treatment conditions | n | Male (%) |
Caucasian (%) |
Attrition rate (%) |
Dose | Post-treatment outcome (% abstinent) |
Follow-up outcome (% abstinent) |
|---|---|---|---|---|---|---|---|---|
| [13] | a) CBT | 23 | 0 | 91 | 17 | 10 sessions (10 weeks) | a) 79* | a) 46% remained abstinent |
| b) Wait-list control | 21 | 0 | b) 0 | |||||
| [20] | a) CBT | 18 | 0 | 86 | 33 | 16 sessions (16 weeks) | a) 28* | NR |
| b) IPT | 18 | 11 | b) 44* | |||||
| c) Wait-list control | 20 | c) 0 | ||||||
| [22] | a) BWLT | 37 | 0 | NR | 27 | 30 sessions (36 weeks) | a) 19 | a) 14 |
| b) BWLT + CBT | 36 | 17 | b) 37 | b) 28 | ||||
| c) BWLT + CBT + desipramine | 36 | 23 | c) 41 | c) 32 (3 month) | ||||
| [105] | a) CBT | 39 | 14 | NR | 14 | 12 sessions (12 weeks) | a) 55* | (see [15]) |
| b) Wait-list control | 11 | 9 | b) 9 | |||||
| [15] | a) BWLT + CBT | 93 | 0 | 92 | 18 | 30 sessions (36 weeks) | a) 33 | NR |
| 1-year follow-up data from [17,22, 105] | ||||||||
| [33] | a) Guided self-help CBT | 24 | 0 | 97 | 33 | Self directed (12 weeks) | a) 50* | a) 41, 50 |
| b) Unguided self-help CBT | 24 | 0 | b) 43* | b) 37, 40 | ||||
| c) Wait-list control | 24 | 4 (12% overall) | c) 8 | (3, 6 months) | ||||
| [35,36] | a) Therapist-led CBT | 16 | 0 | 97 | 12 | 14 sessions (8 weeks) | a) 69* | a) 55, 56, 67 |
| b) Partial self-help CBT | 19 | 10 | b) 68* | b) 69, 70, 85 | ||||
| c) Structured self-help CBT | 15 | 27 | c) 87* | c) 64, 75, 75 (1, 6, 12 months) | ||||
| d) Wait-list control | 11 | 18 | d) 13 | |||||
| [106] | a) CBTgsh | 40 (82.5% BED) | 0 | 95 | 3 | a) 6 sessions (10 weeks) | a) 68* | NR |
| b) CBT unguided self-help | 3 | b) 10 weeks | b) 55 | |||||
| [68] | a) Cognitive therapy | 37 | 0 | NR | 14 | 15 sessions (15 weeks) | a) 67 | a) 86* |
| b) Behavioral therapy | 37 BED = 37 | b) 44 | b) 44 (6 months) | |||||
| [29] | a) CBT | 81 | 17 | 94 | 11 | 20 sessions (20 weeks) | a) 79 | a) 59 |
| b) IPT | 81 | 17 | 91 | 9 | b) 73 | b) 62 (12 months) | ||
| [25] | a) CBTgsh | 37 | 21 | 77 | 13 | Self directed (12 weeks) | a) 46* | No follow-up |
| b) BWLTgsh | 38 | 33 | b) 18 | |||||
| c) Wait-list control | 15 | 13 | c) 13 | |||||
| [25] | a) CBTgsh + orlistat | 25 | 12 | 88 | 24 | 6 brief individual sessions (12 weeks) | a) 64* | a) 52 |
| b) CBTgsh + placebo | 25 | 20 | b) 36 | b) 52 (3 month) | ||||
| [25] | a) CBT + fluoxetine | 26 | 23 | 89 | 23 | 16 sessions (16 weeks) | a) 50* | No follow-up |
| b) CBT + placebo | 28 | 21 | 93 | 21 | b) 61* | |||
| c) Fluoxetine | 27 | 30 | 100 | 22 | c) 22 | |||
| d) Placebo | 27 (108) | 15 (22) | 74 (89) | 15 (20) | d) 26 | |||
| [23,24] | a) BWLT + CBT + fluoxetine | 28 | 22 | 77 | 32 | 16 sessions (BWLT) | a&b) 62* (CBT) | 68, 61, 70, 74 (6, 12, 18, 24 months) |
| b) BWLT + CBT + placebo | 25 | 20 sessions (CBT) | c&d) 33 (BWLT) | CBT>BWL (24 months) | ||||
| c) BWLT + fluoxetine | 32 | (5 months) | ||||||
| d) BWLT + placebo | 31 | |||||||
| [48] | a) Group CBT | 47 | 9 | 98 | 21 | 16 sessions (16 weeks) | a) 62* | a) 65, 68 |
| b) Group psychodynamic IPT | 48 | 23 | b) 60* | b) 62, 57 (12 months) | ||||
| c) Wait-list control | 40 | 18 | c) 9 | |||||
| [31] | a) Group CBT + topiramate | 37 | 3 | 62 | 19 | 19 sessions (21 weeks) | a) 84* | No follow-up |
| b) Group CBT + placebo | 36 | 6 | 53 | 28 | b) 61 | |||
| [16] | a) CBT | 30 | 6 | NR | 7 | 15 sessions (20 weeks) | a) 63* | a & b) 80 (groups analyzed together) (12 month) |
| b) Wait-list control | 22 | 0 | b) 18 | |||||
| [37] | a) CBT | 44 | 9 | NR | 30 | 16 sessions (16 weeks) + 6 monthly follow-up sessions | a) 41 | a) 52 |
| b) BWLT | 36 | 14 | 25 | b) 58* | b) 50 (12 month) | |||
| [107] | a) Group CBT | 22 | 9 | 68 | 32 | 10 sessions (10 weeks) | a) 8 | a) 22 |
| b) CD-ROM CBT | 22 | 9 | 64 | 41 | 10 weeks | b) 13 | b) 13 (2 months) | |
| c) Wait-list control | 22 | 5 | 77 | 9 | ||||
| [108] | a) Adapted motivational interviewing (AMI) | 54 | 0 | 89 | 11 | 1 AMI session + self-Help handbook | a) 28* | NR |
| b) Control | 54 | 15 | Self-help handbook | b) 11% | ||||
| [25] | a) CBT + booster session | 18 | 0 | NR | 6 | 8 sessions (8 weeks) + 5 booster sessions during follow-up | a) 11* | a & b) 41, 23, 25 (3, 6, 12 months) |
| b) Wait-list control | 18 | 0 | b) 0 | |||||
| [109] | a) Psychoeducational treatment (PET) | 13 | 0 | 91 | 8 | 11 sessions (12 weeks) a and | b) 78 (groups analyzed together) | a and b) 87 (12 months) |
| b) Wait-list control | 27 | 59 | ||||||
| [57] | a) DBT-BED | 50 | 14 | 80 | 4 | 20 sessions (21 weeks) | a) 64 | a) 64 |
| b) Active comparison group therapy (ACGT) | 51 | 16 | 73 | 33 | b) 33 | b) 49 (12 months) | ||
| [37] | a) CBT-GSH | 59 | 8 | 98 | 12 | a) 8 sessions (12 weeks) | a) 64* | a) 75*, 64* |
| b) Treatment as usual (control) | 64 (48% BED) | 95 | 6 | b) 28 | b) 44, 45 (26, 52 weeks) | |||
| [39] | a) CBTgsh | 66 | 18 | 82 | 30 | 10 sessions | a) 62 | a) 59, 62 |
| b) IPT | 75 | 15 | 77 | 7 | 20 sessions | b) 67 | b) 55, 64 | |
| c) BWLT | 64 | 11 | 88 | 28 | 20 sessions (24 weeks) | c) 64 | c) 50, 47 (12, 24 months) | |
| [41] | a) CBTgsh (internet-based) | 37 | 0 | NR | 24 | Self directed (6 months) | a) 35* | a) 43 |
| b) Wait-list control | 37 | 11 | b) 8 | b) NR (6 months) | ||||
| [26] | a) CBT | 45 | 36 | 76 | 24 | a & b)16 sessions (24 weeks) | a) 44 | a) 51, 51 |
| b) BWLT | 45 | 38 | 80 | 31 | c) 16 sessions (16 weeks—CBT); 16 sessions (24 weeks—BWLT) | b) 38 | b) 33, 36 | |
| c) CBT followed by BWLT | 35 | 20 | 74 | 40 | c) 49 | c) 49, 40 (6, 12 months) | ||
| [110] | a) CBT + diet | 25 | 24 | 80 | 20 | 21 sessions (6 months) | a) 60 | NR |
| b) CBT + nutritional counseling | 25 | 8 | b) 72 |
*
Significant difference