Table 2.

Interaction of Haplotypic Risk and Treatment Effect on Abstinence at End-of-Treatment in the Wisconsin TTURC Cessation Trial (N=1,073)

	Abstinence at End of Treatment
Predictors	Odds Ratio	95% C.I.	P
Haplotypes (rs16969968-rs680244*)
H1- GC	reference
H2- GT	0.62	(0.33, 1.17)	0.14
H3- AC	0.37	(0.19, 0.75)	0.0057
Treatment Status
Placebo	reference
Active Treatment	0.98	(0.57, 1.69)	0.93
Interaction of Haplotypes and Intervention			(a)
H1* Active Treatment	reference
H2* Active Treatment	1.83	(0.93, 3.63)	0.083
H3* Active Treatment	3.12	(1.48, 6.55)	0.0027

All models were adjusted for age (quartiles) and gender. TTURC = Transdisciplinary Tobacco Use Research Center

^(a)chi squared=8.97, df=2, omnibus p=0.011 for the overall interaction effect.