Table 1.
List of SNPs in the haploinsufficient tumor suppressor genes that created microRNA binding sites in their 3′UTR.
| Gene | Location | SNP ID | Allele change | microRNA binding site created for |
|---|---|---|---|---|
| ATM | 108236469 | rs3092834 | C to T | hsa-miR-4252 |
| 108237460 | rs187308124 | C to T | hsa-miR-4428 | |
| 108237837 | rs227091 | C to T | 4 microRNAs* | |
| 108238032 | rs114847811 | C to T | hsa-miR-600 | |
| 108239075 | rs186644530 | A to G | hsa-miR-2117 | |
| 108239099 | rs191399133 | T to C | hsa-miR-4448 | |
| 108239463 | rs3092852 | C to T | hsa-miR-1265 | |
| BAG1 | 33253621 | rs191119067 | G to C | hsa-miR-4452, hsa-miR-4680-3p |
| CAMTA1 | 7827003 | rs183056496 | G to A | hsa-miR-582-3p |
| 7828815 | rs112733335 | G to A | hsa-miR-342-3p | |
| CDH1 | 68867609 | rs35942505 | C to T | 6 microRNAs* |
| 68868146 | rs140240766 | C to A | hsa-miR-427 | |
| 68868576 | rs9282654 | T to G | hsa-miR-129-1-3p, hsa-miR-129-2-3p | |
| 68869062 | rs33967108 | G to C | hsa-miR-1273a | |
| 68869394 | rs146556488 | C to A | hsa-miR-369-3p | |
| CDKN1B | 12874056 | rs114975362 | G to T | hsa-miR-3919 |
| CHEK1 | 125525308 | rs148807246 | A to G | hsa-miR-1184, hsa-miR-1205, hsa-miR-3158-5p |
| 125545904 | rs192805943 | G to A | hsa-miR-2964a-3p | |
| CLU | 27454684 | rs9331949 | A to G | hsa-miR-1283 |
| CTCF | 67672530 | rs187258944 | G to T | hsa-miR-2276 |
| DFFB | 3800550 | rs146888429 | G to A | hsa-miR-1227 |
| 3800570 | rs140704651 | C to T | 4 microRNAs* | |
| DIRC2 | 122598847 | rs150233566 | G to C | hsa-miR-4797-5p |
| 122599452 | rs180703954 | A to C | hsa-miR-3927, hsa-miR-4451, hsa-miR-4732-5p | |
| ETV6 | 12043995 | rs183579990 | C to G | hsa-miR-3160-3p, hsa-miR-558 |
| 12044403 | rs79663578 | T to A | hsa-miR-5011-5p | |
| 12045614 | rs183305984 | G to A | hsa-miR-3690 | |
| 12045861 | rs72550771 | T to C | hsa-miR-4774-5p | |
| FBXW7 | 153243322 | rs4399968 | G to C | hsa-miR-338-3p, hsa-miR-634 |
| FEN1 | 61564571 | rs141406755 | T to C | hsa-miR-3654 |
| KIF1B | 10365509 | rs180831292 | C to G | hsa-miR-4768-5p |
| 10365953 | rs72640311 | T to G | hsa-miR-1972 | |
| 10366284 | rs115354754 | A to C | hsa-miR-3934, hsa-miR-764 | |
| 10366763 | rs56164683 | A to G | hsa-miR-27a-3p, hsa-miR-27b-3p | |
| 10366766 | rs187140427 | A to T | hsa-miR-376c | |
| 10367056 | rs41274464 | G to A | hsa-miR-148b-5p, hsa-miR-3168 | |
| 10367348 | rs142468272 | C to A | 4 microRNAs* | |
| 10367422 | rs2004034 | G to A | 6 microRNAs* | |
| 10367577 | rs143823495 | G to T | hsa-miR-4494, hsa-miR-4499 | |
| 10367816 | rs145128126 | A to T | hsa-miR-3941, hsa-miR-466, hsa-miR-4672 | |
| 10437247 | rs2155760 | C to T | 8 microRNAs* | |
| 10437802 | rs4240913 | G to A | hsa-miR-645 | |
| 10438336 | rs189264558 | A to G | hsa-miR-516a-3p, hsa-miR-516b-3p | |
| 10439362 | rs186201500 | A to C | hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-644a | |
| 10439538 | rs184232081 | G to A | hsa-miR-4425 | |
| 10440756 | rs192312673 | C to T | hsa-miR-4797-5p | |
| 10440757 | rs148005450 | G to A | hsa-miR-4534 | |
| KLF5 | 73650341 | rs117651109 | C to T | hsa-miR-5579-5p |
| MDM2 | 69235650 | rs144972734 | A to G | hsa-miR-671-5p |
| 69236143 | rs190072365 | C to T | hsa-miR-934 | |
| 69236269 | rs142063414 | G to A | hsa-miR-3198, hsa-miR-4309 | |
| 69236548 | rs1690917 | G to T | 4 microRNAs* | |
| 69237299 | rs183077346 | T to A | hsa-miR-889 | |
| 69237446 | rs150137388 | A to G | hsa-miR-9-3p | |
| 69238249 | rs141938174 | C to T | hsa-miR-4705 | |
| 69238568 | rs148584832 | G to A | hsa-miR-4522 | |
| 69238940 | rs184278637 | G to A | 6 microRNAs | |
| PAX5 | 36839029 | rs184505592 | G to C | hsa-miR-4520a-3p |
| PPARA | 46631658 | rs4253801 | A to G | hsa-miR-4709-5p |
| 46631718 | rs183307497 | A to G | hsa-miR-5095, hsa-miR-600 | |
| 46631838 | rs188241700 | T to G | hsa-miR-1470, hsa-miR-4287, hsa-miR-4685-3p | |
| 46632587 | rs9615264 | G to A | hsa-miR-1231 | |
| 46632932 | rs181140325 | T to A | hsa-miR-4277 | |
| 46633120 | rs78922364 | G to C | hsa-miR-499b-5p | |
| 46633549 | rs115356860 | C to T | hsa-miR-892b | |
| 46633564 | rs148478205 | C to T | hsa-miR-4252 | |
| 46634352 | rs184920139 | G to A | hsa-miR-301a-5p | |
| 46634514 | rs41418950 | C to T | hsa-miR-936 | |
| 46635061 | rs41403648 | G to A | hsa-miR-3944-5p, hsa-miR-5094 | |
| 46636623 | rs56180992 | G to A | hsa-miR-515-5p, hsa-miR-519e-5p | |
| 46637760 | rs181781384 | A to G | hsa-miR-4733-3p | |
| 46638155 | rs1055658 | G to C | hsa-miR-744-5p | |
| 46638209 | rs79700435 | G to A | hsa-miR-3191-5p, hsa-miR-518c-5p | |
| 46639161 | rs187605878 | A to G | hsa-miR-3157-3p | |
| 46639611 | rs117317496 | G to C | hsa-miR-5584-5p | |
| PTCH1 | 98205709 | rs28413010 | A to T | hsa-miR-126-5p, hsa-miR-4795-3p |
| 98206995 | rs41316950 | C to G | hsa-miR-4690-3p, hsa-miR-5685 | |
| PTEN | 89725452 | rs3895069 | T to G | hsa-miR-5003-5p |
| 89726622 | rs79395513 | C to A | hsa-miR-651 | |
| 89726726 | rs180953647 | C to T | hsa-miR-510 | |
| RAD50 | 131980172 | rs146790944 | A to G | hsa-miR-300, hsa-miR-381 |
| 131980267 | rs139468574 | A to G | hsa-miR-4524a-5p, hsa-miR-4524b-5p | |
| 131980270 | rs75939007 | A to G | 4 microRNAs* | |
| RB1 | 49054521 | rs187845274 | T to A | hsa-miR-4638-3p |
| 49054779 | rs150194261 | T to C | hsa-miR-145-5p, hsa-miR-5195-3p | |
| 49055241 | rs192758219 | G to T | hsa-miR-1323, hsa-miR-548o-3p | |
| RXRA | 137328831 | rs1805346 | G to A | hsa-miR-3688-3p |
| 137328936 | rs189590058 | C to T | hsa-miR-4738-3p | |
| 137329304 | rs4240711 | G to A | hsa-miR-3184-3p | |
| 137329411 | rs34449651 | G to C | hsa-miR-3919 | |
| 137329652 | rs35283205 | G to C | hsa-miR-4685-5p | |
| 137330306 | rs180869938 | T to C | hsa-miR-1908, hsa-miR-663a | |
| 137330727 | rs17847916 | C to T | hsa-miR-4721 | |
| 137330802 | rs10119893 | G to A | 5 microRNAs* | |
| 137330980 | rs139882385 | T to C | hsa-miR-518a-5p, hsa-miR-527 | |
| 137331443 | rs139749844 | G to A | hsa-miR-3170, hsa-miR-5572 | |
| 137331999 | rs11103561 | G to A | hsa-miR-4722-3p, hsa-miR-4769-3p | |
| 137332362 | rs187745805 | G to A | hsa-miR-5010-3p, hsa-miR-599 | |
| 137332378 | rs137912651 | G to C | hsa-miR-301a-5p | |
| SERPINB5 | 61171674 | rs112795011 | A to C | hsa-miR-4535, hsa-miR-4776-5p |
| SMAD4 | 48605247 | rs28403611 | A to G | hsa-miR-552 |
| 48605297 | rs191822473 | G to A | hsa-miR-656 | |
| 48605643 | rs183984903 | A to G | hsa-miR-5095 | |
| 48607107 | rs189547031 | G to C | hsa-miR-5584-5p | |
| 48607497 | rs191637734 | A to T | hsa-miR-421, hsa-miR-4272 | |
| 48608123 | rs191317135 | C to T | hsa-miR-3163 | |
| 48609056 | rs150556996 | G to T | hsa-miR-4496 | |
| 48609588 | rs112739300 | C to T | hsa-miR-297, hsa-miR-3149, hsa-miR-675-3p | |
| 48609716 | rs184516281 | T to C | hsa-miR-584-3p | |
| 48609918 | rs145596898 | G to A | hsa-miR-4694-3p | |
| 48610254 | rs146551171 | T to C | 23 microRNAs* | |
| 48610822 | rs12954419 | T to A | hsa-miR-5696 | |
| 48610844 | rs181250637 | G to C | hsa-miR-636 | |
| 48611357 | rs183472455 | C to T | hsa-miR-371b-5p, hsa-miR-373-5p, hsa-miR-616-5p | |
| SOX9 | 70121452 | rs74999341 | T to C | hsa-miR-4759 |
| 70121525 | rs185467299 | C to T | hsa-miR-4514, hsa-miR-4692, hsa-miR-4742-5p | |
| TNFAIP3 | 138202555 | rs140042278 | G to T | hsa-miR-208a, hsa-miR-208b, hsa-miR-499a-5p |
| 138202864 | rs76710415 | A to C | hsa-miR-4533 | |
| 138203096 | rs73778206 | T to C | hsa-miR-223-3p | |
| 138203386 | rs191520762 | T to G | hsa-miR-4772-3p | |
| 138203884 | rs73778207 | G to A | hsa-miR-96-3p | |
| TP53 | 7572039 | rs35659787 | G to A | hsa-miR-516b-5p, hsa-miR-518c-5p |
| 7574010 | rs17882252 | G to A | hsa-miR-127-5p | |
| 7574015 | rs121912664 | G to A | 12 microRNAs* | |
| VHL | 10191771 | rs34362094 | C to T | hsa-miR-5579-5p |
| 10192172 | rs190102073 | A to G | hsa-miR-4448 | |
| 10193434 | rs115303528 | G to A | hsa-miR-592, hsa-miR-599 | |
| 10193848 | rs145666034 | G to A | hsa-miR-3545-3p | |
| 10194195 | rs187719061 | A to G | hsa-miR-371a-5p |
Notes: This table enlists the 129 SNPs that create new miRNA binding sites in the 3′UTR of their respective haploinsufficient tumor suppressor gene. Table compiled from the data provided by PolymiRTS database.
*
For convenience these microRNAs are not indicated in the table, and for details the reader is referred to Supplement 2.