Table 2.
SNPs in miR seed and their new target haploinsufficient genes.
| miR ID | SNP ID | miR seed | Allele | Haploinsufficient gene targets |
|---|---|---|---|---|
| hsa-mir-125a | rs12975333 | CCCUGA[G/U] | G/T | ATM, MSH2 |
| hsa-miR-1268 | rs28599926 | GGGC[G/A]UG | G/A | ATM, PAX5, PPARA, PTEN, NBN |
| hsa-miR-1469 | rs116596918 | UCGGC[G/C]C | C/G | DDB2, FOXP1 |
| hsa-miR-3610 | rs112072631 | AAUCGG[A/C] | C/A | SERPINB5, SMAD4 |
| hsa-miR-3615 | rs112977728 | CU[C/U]UCGG | C/T | RAD50, NBN, TP53BP2 |
| hsa-miR-3618 | rs12159555 | GU[C/G]UACA | C/G | DFFB, PPARA, SMAD4, FOXP1 |
| hsa-miR-3689b | rs116838571 | GUGAU[A/U]U | T/A | CDH1, CDKN1B, FBXW7, RB1, VHL, BRCA2, ROR2, TP53BP2, YWHAE |
| hsa-miR-379 | rs61991156 | GGUAG[A/G]C | A/G | CAMTA1, DFFB, TNFAIP3, VHL |
| hsa-miR-4257 | rs74743733 | CAGA[G/A]GU | A/G | CHEK1, DIRC2, ETV6, PAX5, SOX9 |
| hsa-miR-4284 | rs11973069 | GGCUCA[C/U] | C/T | BAG1, ETV6, TP53BP2 |
| hsa-miR-4305 | rs4636784 | CUA[G/C]ACA | G/C | CDH1, DFFB, FBXW7, KIF1B, PTEN, SMAD4, FOXP1, NBN, MDM2 |
| hsa-miR-4322 | rs114399468 | UGUGG[G/A]C | A/G | CHEK1, KIF1B, PTEN, RAD50, SERPINB5 |
| hsa-miR-557 | rs78825966 | UUUGCA[C/U] | C/T | BAG1, CHEK1, BRCA2, RPL37A, KLF5 |
| hsa-miR-585 | rs62376935 | GG[G/A]CGUA | G/A | BAG1, KIF1B, NBN, TP53BP2 |
| hsa-miR-605 | rs113212828 | [A/G]AAUCCC | A/G | RAD50, RB1, VHL, MSH2 |
| hsa-miR-642a | rs78902025 | UCCC[U/G]CU | G/T | ATM, PPARA, SERPINB5 |
| hsa-miR-642b | rs111664333 | GA[C/U]ACAU | T/C | ATM, RAD50, SMAD4, NBN, TP53BP2 |
| hsa-miR-936 | rs79924817 | C[A/G]GUAGA | G/A | ATM, BAG1, PPARA, RAD50, XPO5 |
| hsa-miR-938 | rs12416605 | [G/A]CCCUUA | G/A | BAG1, PPARA, PTEN, SMAD4, SOX9, TNFAIP3, XPO5, MDM2 |
Notes: This table represents the miR-SNPs that render microRNAs to bind with non-specificity to haploinsufficient tumor suppressor genes. Table compiled from the data extracted from PolymiRTS database.