Supplement I.
List of Haploinsufficient genes known to be involved in tumorigenesis.
| Haploinsufficient genes | References |
|---|---|
| ANX7, APC, ARF, ATM, BAG1, BECN1, BRCA1, BRCA2, BUBR1, CAMTA1, CAV1, CDKN1B, CDKN1C, CDKN2B, CSN5, CTCF, DFFB, DIRC2, EEF1E1, ETV6, FBXW7, FOXP1, H2 AX, INI1, INK4C, KLF6, LIG4, LIS1, LKB1, MEL-18, MYH, NHERF1, NKX3–1, NPM1, P53, PAX5, PLK4, PPARA, PPARG, PRKAR1 A, PTCH1, PTEN, RAD50, RASSF1 A, ROR2, RPRM, SAM68, SERCA2, SMAD5, SOCS1, SOX9, SPRED1, ST7, TGFB1, TP53BP2, TP73, TRAPPC2, TSC1, TSC2, VHL, WT1, WWOX, YWHAE | 11 |
| ATR | 18 |
| BIM (BCL2 L11) | 17 |
| BLM | 21 |
| BUB3 | 30 |
| CDH1 | 44 |
| CDKN1 A | 28 |
| CHK1 (CHEK1) | 33 |
| CLU | 9 |
| CREBBP (CBP) | 49, 47, 5 |
| DDB2 | 26 |
| DGCR8 | 42 |
| DICER1 | 32, 2, 41 |
| DLL4 | 19, 23 |
| DMP1 | 25, 51, 34 |
| DOK2 | 4 |
| FBXO11 | 14 |
| FEN1 | 31 |
| IKZF1 (IKAROS) | 39, 29, 52 |
| KIF1Bβ | 40 |
| KLF5 | 10 |
| MAD2 L1 | 38 |
| MDM2 and MDM4 | 50 |
| MLH1 | 48 |
| MSH2 | 12, 13, 6 |
| MUS81 | 36 |
| NBN | 15 |
| NF1 | 27, 59 |
| NF2 | 35 |
| PINX1 | 58 |
| RAD17 | 8 |
| RB1 | 53, 57 |
| Ribosomal proteins (RPL35, RPL37 A, RPS19 and RPS8) | 1 |
| RPS14 | 16, 3 |
| RUNX1 | 45 |
| RXRA | 24 |
| SERPINB5 (Maspin) | 43 |
| SMAD4/DPC4 | 56 |
| TARBP2 | 37 |
| TIP60 | 20 |
| TNFAIP3 | 55, 7 |
| TP53BP1 | 54 |
| TP63 (TAp63) | 46 |
| XPO5 | 22 |