Effect of CP on body weight (A), epididymal white adipose tissue mass-to-body weight percentage (B), gross appearance (C and D), and histological section (E and F) in saline- and CP-treated mice. There was a 40% reduction in wet weight of epididymal white adipose tissue in CP-treated mice (B) compared with saline-treated mice. Epididymal white adipose tissue (shown by black arrows) in CP-treated mice appears white in saline-treated compared with the red color in CP-treated mice. Histological changes in epididymal white adipose tissue after CP treatment are shown. Sections of epididymal white fat tissue obtained from saline (E)- vs. CP (F)-treated mice were stained with hematoxylin-eosin. E: saline-treated mice have unremarkable adipose tissue, ×100. F: epididymal fat tissue of CP-treated mice showed focal adipocyte necrosis (long thin arrow) with rare neutrophil (short thick arrow) and lymphocyte infiltration (short thin arrow), ×100. Error bars indicate SE. *P < 0.05 compared with day 0 by unpaired Student's t-test.