Table III. Receiver operating characteristics from IHC scores of the three proteins in distinguishing NBE from preneoplastic lesions (SM, AH, and CIS) individually and as a panel. PPV, positive predict value; NPV, negative predict value; AUC, area under the curve.
Proteins | Sensitivity | Specificity | PPV | NPV | AUC |
---|---|---|---|---|---|
HSPB1 | 0.85 | 0.65 | 0.88 | 0.50 | 0.79 |
GSTP1 | 0.80 | 0.63 | 0.87 | 0.55 | 0.78 |
CKB | 0.74 | 0.61 | 0.88 | 0.43 | 0.75 |
A panel of three proteins | 0.96 | 0.92 | 0.97 | 0.86 | 0.98 |