Table II. Metabolite changes in malignant glioma vs. control patients.

Metabolite	ID	Fold change (Malignant glioma vs. control)	p value
biotin	C00120	2.96	1.03E-06
glucono.d-lactone	C00198	2.14	6.57E-06
dihydroorotate	C00337	2.19	1.65E-05
orotate	C00295	2.15	1.80E-05
2,3-dihydroxybenzoic acid	C00196	2.13	2.96E-05
Indole.3-carboxylic acid	HMDB03320	1.88	7.93E-05
Acetylcarnitine DL	C02571	5.23	1.30E-04
Aminoadipic acid	C00956	1.90	1.82E-04
proline	C00148	2.83	1.23E-03
Phenyllactic acid	C01479	1.56	1.30E-03
2.Hydroxy.2-methylbutanedioic acid	C02612	0.22	1.59E-03
Phenylpropiolic acid	HMDB00563	1.26	1.78E-03
dTMP	C00364	1.53	4.93E-03
N6-Acetyl-l-lysine	C02727	1.46	5.27E-03
oxaloacetate	C00036	1.77	6.80E-03
Acetyllysine	C02727	1.45	8.51E-03
shikimate	C04236	3.69	8.61E-03
Atrolactic acid	HMDB00475	1.66	1.26E-02
methionine	C00073	2.27	1.27E-02
taurine	C00245	1.50	1.29E-02
purine	C00465	1.47	1.48E-02
N-acetyl-glutamine	HMDB06029	1.43	1.80E-02
2-ketohaxanoic acid	HMDB01864	3.16	1.93E-02
ribose-phosphate	C00117	0.73	2.15E-02
myo-inositol	C00137	0.65	2.27E-02
lysine	C00047	1.54	2.86E-02
glucosamine	C00329	1.38	3.02E-02
adenine	C00147	0.49	3.23E-02
nicotinamide	C00153	0.34	3.40E-02
thiamine	C01081	7.99	3.51E-02
phenylalanine	C00079	1.34	3.53E-02
S-methyl-5-thioadenosine	C00170	1.50	4.07E-02
hypoxanthine	C00262	0.72	4.14E-02
isocitrate	C00311	0.72	4.36E-02
serine	C00065	1.58	4.74E-02
7-methylguanosine	HMDB01107	1.59	4.85E-02
glutamine	C00064	1.36	4.85E-02
glucose.1-phosphate	C00103	0.91	4.86E-02