Table II. Pathway over representation analysis of uncommon proteins differentially phosphorylated in response to West African MPXV infection.
| Pathway Name | Proteins in Pathway | Increased Phosphorylations | Up-Regulated Pathway P Value | Decreased Phosphorylations | Down-Regulated Pathway P Value |
|---|---|---|---|---|---|
| FGF signaling pathway | 6 | 6 | 0.027 | 0 | 1 |
| IL2 | 6 | 6 | 0.027 | 0 | 1 |
| ErbB1 downstream signaling | 9 | 8 | 0.034 | 1 | |
| Signaling events mediated by TCPTP | 5 | 5 | 0.052 | 0 | 1 |
| IL6 | 8 | 7 | 0.062 | 0 | 1 |
| KitReceptor | 4 | 4 | 0.099 | 0 | 1 |
| LPA receptor mediated events | 4 | 4 | 0.099 | 0 | 1 |
| PDGFR-beta signaling pathway | 4 | 4 | 0.099 | 0 | 1 |
| Regulation of nuclear SMAD2/3 signaling | 4 | 4 | 0.099 | 0 | 1 |
| TGF-beta receptor signaling | 6 | 1 | 1 | 5 | 0.027 |
| ALK1 signaling events | 3 | 0 | 1 | 3 | 0.054 |
| Chronic myeloid leukemia | 7 | 2 | 0.99 | 5 | 0.070 |
| Colorectal cancer | 7 | 2 | 0.99 | 5 | 0.070 |